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Neurontin is an anticonvulsant that is used for preventing seizures and treating postherpetic neuralgia. The mechanism action of this drug is yet unknown. This drug structurally resembles the neurotransmitter gamma aminobutyric acid. It is also possible that this similarity is related to gabapentin’s mechanism of action. In animal studies, testing the anticonvulsant and analgesic activity of drugs prevents seizures and reduces pain-related responses. The Food and Drug Administration approved this drug last December 1993.
Neurontin is approved for treatment of seizure disorders and nerve damage from herpes zoster. There are many non-approved uses for Neurontin and these include headaches ,alcohol withdrawal, cocaine withdrawal, hiccups, restless leg syndrome, hyperhidrosis, diabetic neuropathy, hot flashes, and fibromyalgia.
This drug may be taken with or without food and it is recommended dose for postherpetic neuralgia is 1800 mg daily in 3 divided doses. The initial dose of this drug 300 mg daily is increased over several days to the recommended daily dose. Seizures are treated with 900-1800 mg/daily in 3 divided doses and withdrawal of treatment should occur slowly over a week.
Antacids reduce the concentration of Neurontin in blood. Therefore, Neurontin should be administered 2 hours or more after taking antacids. Morphine significantly increases blood concentrations of this drug and may increase central nervous system-related adverse events associated with Neurontin.
Neurontin is secreted in human breast milk. Nursing mothers should only use this drug if the benefits outweigh the unknown risk to the fetus.
Common side effects of gabapentin are fluid retention, dizziness, somnolence, ataxia, fatigue, hostility, nausea and vomiting. Other adverse events associated with this drug include: hypertension, joint pain, anorexia, bruising, motion sickness, and pneumonia.
Antiepileptic medications have been related with increased risk of suicidal thinking and behavior. Anyone considering the usage of antiepileptic drugs must balance this risk of suicide with the clinical need. Patients who are started on therapy should be closely observed for suicidal thoughts, clinical worsening or unusual changes in behavior.